Being a lefty in a right-handed world can lead to a lot of wear and tear. You’re not just looking at awkward handshakes or the fight to operate a simple pair of scissors. Left-handedness affects everything, from how you drive to how you sit to how you use a computer.
Anyone who has tried to use a right-handed mouse with a dominant left hand understands our pain. Awkward mousing, missed cues in a raid party, and accidentally clicking on things you never meant to see.
We have been there and done that. We have tried not to be left (ha!) behind as our right-handed brethren and sisters zoom ahead, happily clicking and mousing away.
So for you, we have researched dozens of products to find you the best lefty mouse.
What Should You Look for in an Ergonomic Mouse?
Righty, lefty, or ambidextrous–you want a mouse that is comfortable to use.
OSHA studies  observed degradation and inflammation of hand, arm, and shoulder muscles caused by constant hand pressure on the mouse and by moving a mouse held over 15 inches from the body (that’s one heck of a reach!).
A better mouse may help reduce aggravation and some find it helpful in preventing physical issues like carpal tunnel syndrome.
So what makes a great ergonomic mouse?
One popular type of mouse for ergonomics is the trackball mouse, which uses a ball in the center or on one side that can be used to control the cursor.
Whether you control the trackball directly with your fingertips or use your thumb to guide the trackball motion, you may find this type of trackball much more comfortable.
A trackball mouse requires only slight movements of hand or arm, which cuts down on repetitive stress against your wrist, elbow, and shoulder joints.
Mice that are symmetrically designed and can be used in either hand (ambidextrous) are a great ergonomic pick.
This allows you to cycle between hands as they become fatigued, better distributing the work and reducing strain.
A vertical mouse design better fits the contours of the hand and promotes a more neutral wrist position.
This reduces the need to grip the mouse in awkward positions. Because they follow the natural curve of the palm and fingers, many find them an easy adjustment and a comfortable alternative to traditional mice.
Some vertical mice have a contoured design. Others have a C-shape that fits between your index finger and your thumb. Both often offer wrist support and help minimize unnecessary movement.
We found vertical mouse designs as varied as their users, such as the unique Posturite Penguin. The Posturite earns its name with its eye-catching pillar-style design that resembles a penguin and it even comes in different sizes.
Roller Bar Design
An alternative to the vertical mouse is the roller bar mouse. It’s not much different from a laptop touchpad or embedded laptop trackballs or “eraser” style mouse tracking nodes–remember those? We do. Are we showing our age?
So how is a roller mouse different? It’s an external peripheral, rather than integrated for laptop and desktop users. It has a cushioned bar positioned below your keyboard, reducing the arm extension required to reach the mouse.
The Best Left-Handed Mouse for You
So we know what makes a great ergonomic mouse. But we’ve still got to face the harsh truth: they make most mice for right-handed users, and finding the best left-handed mouse means weeding through hundreds of products that just aren’t made for us.
But never fear–we’ve done the heavy lifting for you. Without further ado, here are our top four mice for left-handed users.
Kensington Orbit with Scroll Ring – Best Value Left-Handed Mouse
This general-purpose trackball mouse is a popular pick and sports a budget-friendly price tag.
With a built-in scroll wheel that provides a smooth scrolling experience, this mouse is highly usable. The comfortably sized 40mm trackball also allows versatile finger movements during operation, allowing users to distribute work across different muscles and fingers as needed.
You can read our longer review of it here.
- Ambidextrous design, enabling you to switch your preferred hand as needed
- In-built scroll wheel, allowing easy navigation and browsing
- Trackball design minimizes hand, wrist, arm, and shoulder movement to reduce potential strain and injuries
- No batteries needed
- Easy USB plug and play, and compatibility with Mac & Windows
- Limited options for advanced shortcuts or functionality, with only two basic “left and right” buttons
- Wired only
- May be a little wide for users with small hands
ELECOM Left-Handed 2.4GHz Wireless Easy Thumb Control Trackball Mouse – Best Bluetooth Left-Handed Mouse
Cord management can be cumbersome and even more annoying when so many workstations keep cords out of the way of the right hand–while the left gets entangled.
Switching to a wireless mouse can avoid the cord tangle and let you position your mouse for more comfortable ergonomic use without your mouse yanking you back by the leash.
Users report liking the hand fit and thumb trackball.
- Comes with a USB Bluetooth adapter for quick connectivity and setup
- Design encourages hand relaxation
- Built-in scroll wheel in a comfortable position
- Programmable buttons
- Button programming can be limited
- Some users report trackball quickly attracts dirt and requires frequent cleaning
- Occasionally has wireless connectivity glitches, depending on the connected device
- May be a bit small for larger hands
SteelSeries Sensei Ten – Best Left-Handed Mouse for Gaming
If you’re into your gaming, you may want to consider this mouse.
It is an adjustable DPI mouse, which greatly increases fine precision control over mouse movements, which is critical for most modern, fast-paced games.
Another feature users find valuable is the eight programmable buttons for more efficient usage tailored to your needs or required shortcuts.
- 18,000 DPI for fine-tuning performance
- An ambidextrous design that works for righties or lefties
- Tapered contour, making it easier to reposition your hand for comfort
- Eight programmable buttons positioned on both sides, enabling thumb clicking patterns
- Mechanical switches for better responsiveness
- Adjustable RGB lighting
- Could be improved with adjustable weighting
- Poor energy efficiency – powered by AAA batteries, which drain quickly
- Side buttons are a little small and can lead to over-or-under-reach
- Some report occasional connectivity issues
Perixx Perimice-513L Wired Vertical Ergonomic Mouse – Best Left-Handed Mouse on a Budget
Sometimes you just don’t have the cash for an expensive mouse. If you’re looking for a low-cost left-handed ergonomic mouse, one great option is the Perixx wired vertical mouse. It’s also the top vertical mouse on our list, making it a two-for-one powerhouse.
Low-cost doesn’t have to mean low-quality. For the price, we found the Perixx excellent for budget users.
- Contoured vertical design for additional comfort and usability
- Made just for lefties
- Built-in scroll wheel with smooth functionality
- Six programmable buttons
- Option for wired if connection reliability & latency is important
- Offered also as a wireless model if you crave to be cut free from the cord
- Only two settings for adjustable DPI
- Doesn’t function well without a mouse pad
- Some users find the buttons have high resistance
- Low-cost materials mean faster wear and tear, leading to frequent replacements
Making the Most of Your Ergonomic Mouse
Finding the right mouse is only part of the equation.
For optimal comfort, you need to adjust your mouse usage habits. Monitor your grip strength, and focus on using a lighter touch for less hand strain. Find the best position for your mouse and keyboard to minimize arm and hand reach.
Pair good ergonomic practices with the right left-hand mouse–pun intended–and you’re well on your way to an ideal computer setup.