You might be able to get away with occasionally using the wrong mouse size.
But when most computer users are using their mouse almost three times as much as their keyboard , you could be setting yourself up for Workplace Musculoskeletal Disorders  (WMSDs).
If you have hands that are larger than average, here are the top 5 wireless mice that may help.
iClever Ergonomic Mouse – Wireless Vertical Mouse
With dimensions of 5.43 x 2.95 x 2.68 inches (LxWxH), the iClever is well-suited for the large-handed user.
The “open ended” design lets you choose how closely you hold the mouse, without compromising support. When your hands are very big, that helps you leave some distance between the palm and the edge of the mouse.
iClever buttons are smooth and quiet, and take less effort to depress.
The diamond pattern grooves give your palm a better grip, and allow air circulation to evaporate sweat. Your palm will stay cool while you work for long hours.
And speaking of grooves, there’s one for your pinky too, and extra comfort is included in the form of skin-friendly materials.
A DPI indicator shows when you switch among the three DPI settings, and Backwards and Forward page buttons offer convenience. There’s also an impressive wireless range of 33 feet.
- Vertical design
- Smooth and quiet clicking
- Storage hole for the USB dongle
- Needs two AAA batteries (not included)
- No software options
- No Bluetooth connectivity
Logitech MX Master 3 Wireless Mouse
The Logitech MX Master 3 offers hours of comfort for users with large hands. This is all credit to the ergonomic design that incorporates a large thumb rest and round shape. The Master 3 also comes with a latex covering for an improved grip.
It is especially suited for you if you’re a palm grip user, and if you are right-handed. And as someone with large hands, you will also love that the Master 3 has a sturdy feel and is very well-built.
Dimensions of the Master 3 are 4.92 x 3.31 x 2.01 inches.
Your work speed and productivity will receive a boost with the Electromagnetic Scroller in the Logitech MX Master 3 – it is up to 80% faster than normal basic mouse scroll wheels. Other features like programmable buttons and gesture controls add to the workflow efficiency this mouse provides.
The 4000 DPI setting allows for detailed accuracy when moving the cursor around. That’s way more sensitivity than many other computer mice.
The MX Master 3 offers Bluetooth pairing with up to three devices. Customizable profiles are a plus for setting up and saving new mouse profiles for different applications. You can even copy and paste a folder from one computer to another. All this across different operating systems!
Batteries are easily recharged via a USB-c charger. But when you’re getting up to 70 days between charges, that’s not something you will need to do too often.
- Bluetooth connectivity for three devices
- Customizable profiles
- Great battery life
- Comfortable grip
- Compatible with both Windows and macOS.
- Connectivity might be a problem when several devices connect via wireless adapter
- Right-handed users only
Inphic Large Ergonomic Wireless Mouse
The Inphic is designed for medium to large size hands, having dimensions of 4.25 x 1.22 x 3.18 inches. With a ring/pinkie rest on the side, your ring or pinkie finger will have valuable extra support for hours of work. It comes with sweat-resistant material and is contoured to fit the shape of your palms.
These tiny features may seem like frills on a computer mouse, but when you have large hands sore from long hours, a pinkie rest might mean the world.
The Inphic mouse can go from fully drained to fully charged in almost one and a half hours with a USB 2.0 charger.
It is a suitable mouse for night time work, or public spaces, because the button clicks and scroll wheel are silent.
There is also a power-saving feature, where five minutes of no activity triggers a sleep mode. When you’re ready to resume work, lightly shifting the mouse will reactivate it.
With five adjustable DPI settings, the Inphic gives you a wide DPI range. That means you can change the cursor sensitivity quickly, depending on your work needs.
If you’re left-handed or if you like to switch hands when mousing , the Inphic is the perfect choice because of its ambidextrous design.
It’s also compatible with Windows Vista and Mac OS.
- Ambidextrous design
- Compatible with Windows and Mac
- Silent clicks
- Wide DPI range
- Power-saving mode
- No Bluetooth connectivity
Lekvey Left Hand Mouse
Left-handed people are outnumbered by right-handed people by about 9 to 1. Thankfully, the Lekvey computer mouse is available not just for lefties, but specifically for large-handed lefties.
With dimensions of 5.0 x 3.0 x 2.5 inches, the Lekvey offers a vertical design which gives ergonomic relief to your wrist. Wrist relief comes from the neutral “handshake” positions that make movement smoother and reduce strain.
The Lekvey boasts an open-ended design that lets you decide how closely you want to grip the mouse.
Forward and Back buttons are located where your thumb goes, and the button on the top cycles through 3 DPI settings of 800, 1200 and 1600.
Left and right clicks are, of course, reversed, since the mouse is boldly designed for left-handed use.
Sleeping mode is automatically activated after being idle for 8 minutes. Pressing the right or left button will wake it up immediately. You also have the choice of saving power by using an independent On/Off switch found at the bottom of the mouse.
Six buttons increase the control you can have over your computer systems. There is no compatibility with MacOS.
- Made for the left-handed
- Vertical design for healthy wrist position
- Convenient Back and Forward buttons
- Noiseless buttons
- Not compatible with MacOS
- Needs 2 AAA batteries
- Noiseless clicks may take some getting used to
Kensington Pro Fit Full-Size Wireless Mouse
This full size mouse offers ergonomic relief for long hours of working. Its dimensions are length 4.75″, width 3″ and height of 2″.
The contours are designed to match the natural curvature of your hand, which means less pain and soreness after a long day. There is also a soft rubber grip to make your user experience all the more comfortable.
Bluetooth technology supports this mouse’s connection to your computer, and for laptops without Bluetooth, you can use a Bluetooth 4 dongle. Unfortunately, this dongle is not supplied with the package.
2.4 GHz wireless connectivity allows for long range and stable connection. Forward/back buttons make browsing web pages quick and efficient. The Kensington Pro-fit also uses HD sensor technology to precisely track its movement on any surface, including glass.
Optical sensors allow up to 1200 DPI that can easily be adjusted with the DPI button near the scroll wheel.
- No drivers required
- Compatible with Windows 8
- Connects to the laptop through Bluetooth technology
- Contours designed to fit large hands
- Not compatible with non-Bluetooth devices
- Right-handed only
Buying Guide for the Best Mouse For Large Hands
Is it ambidextrous?
Ambidextrous design is useful for left-handed users. It’s also great for users who want the benefits of switching their hands freely. Strictly left-handed mice like the Lekvey are available too. Otherwise, right-handed models are the standard.
Your hand and finger muscles may fatigue soon without ergonomics in a mouse. Look for sculpted curvature that fits your hand, along with thumb and pinkie rests. The material should allow a firm and comfortable grip, and should ideally prevent too much sweating.
Weight of the mouse
Lightweight mice are easier to move around than bulky mice. Heavier mice are harder to move and can eventually put more strain on your hands. However, when you already have large hands, this may not be much of a problem.
Value of DPI
The higher the DPI (dots per inch), the farther the cursor on your screen will move when you move the mouse. DPI generally matters most to gamers, rather than for browsing the web or working on a spreadsheet. A mouse with good precision can also be important to you if you’re a graphic artist or designer.
The average mouse has 3 buttons including the two side clicks and a middle scroll button. Others have 5-6 or even more buttons for macros, and gaming. If you’re a programmer or serious gamer, you’ll love having extra buttons.
Although we are already dealing with large mice, there are still unique variations in dimension. Length, width and height can make a difference based on the size of your hand and your grip style.
At the very least, make sure of your hand size by measuring from the base of your wrist to the top of your middle finger. If the measurement is above 20cm, you have large hands, and could use a large size mouse.